3 days in Northeast Missouri Itinerary

Test the local claim that Saint Louis is second only to Washington, D.C.

Saint Louis is known for museums, zoos & aquariums, parks, historic sites, and nightlife. Your plan includes some of its best attractions: take in the architecture and atmosphere at Cathedral Basilica of Saint Louis, examine the collection at City Museum, take in nature's colorful creations at Missouri Botanical Garden, and take in panoramic vistas at The Gateway Arch.

Discover how to plan a Saint Louis trip in just a few steps with Inspirock's itinerary builder.

Chicago to Saint Louis is an approximately 3.5-hour flight. You can also do a combination of train and flight; or drive. Traveling from Chicago in November, you will find days in Saint Louis are somewhat warmer (56°F), and nights are about the same (35°F). Finish up your sightseeing early on the 22nd (Fri) so you can travel back home.